Welcome to Dhayalan Group (OMC)
Our OMC group's research focuses on the “Total Synthesis of Natural Products and Active Drug Molecules” using organo- and metal-catalysts for biomedical applications and agricultural development. In this line of research, small ligand and substrate libraries bearing substituents that could be systematically varied, e.g., steric and electronic perturbations, were created and studied to construct mathematical models. Using these models, it was possible to predict the optimal substituents for certain asymmetric regio- and chemo-selective reactions.
A second major research interest is the design and novel synthesis of air- and water-stable organometallic reagents, their functionalization, and the preparation of bioactive heterocycles for medicinal applications. Late-stage modification of biologically active organic compounds using modern organometallic reagents and TMP-M bases.
Recent Hot paper: Dhayalan et al. 2026: Chemical Reviews: Impact factor: 64.2
2024: Chemical Society Review: Impact factor: 48.3
Dr. V. Dhayalan, MSc, Ph.D.
(Assistant Professor)
Organometallic Chemistry and Catalysis (OMC)
Position availability (current opening):
PhD: 2 (with JRF, NET, GATE qualified Students)
Project Assistant/Associate: 1
Prof. Susumu Kitagawa, Richard Robson, and Omar M. Yaghi
The 2025 Nobel Prize in Chemistry was awarded for developing metal-organic frameworks (MOFs)
Prof. Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless
The Nobel Prize 2022 for the development of "Click Chemistry" and Bioorthogonal Chemistry
Prof. Benjamin List & Prof. David WC MacMillan
The Nobel Prize 2021 for developing a new way for building
molecules known as “asymmetric organocatalysis.”
Prof. Richard F. Heck, Prof. Ei-ichi Negishi, Prof. Akira Suzuki
The Nobel Prize in Chemistry 2010 was awarded jointly to Richard F. Heck, Ei-ichi Negishi and Akira Suzuki "for palladium-catalyzed cross couplings in organic synthesis"
PAST EVENTS
International Conference on Emerging Trends in Synthetic Organic Chemistry-2021 (ICETSOC-2021)
on 6-7, December 2021 by (Virtual Mode)
Organized by Dr. V. Dhayalan, et al.
Department of Chemistry
National Institute of Technology Puducherry
Karaikal - 609 609, India
For more details, visit https://nitpychemconf2021.wixsite.com/organic-lab
RECENT NEWS
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Ms. Jyashree and Ms. Savita from ICT-IOC Bhubaneswar have received the Best Research Awards (3rd year PhD, 2025–2026), which the OMC group is celebrating. More than ten research papers were published during the PhD study.
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Chemical Reviews accepted the paper with the highest impact factor (55.8). Thanks to the co-authors and Prof. Knochel.
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Congratulations to Ms. Solanke, J. N., and Ms. Savita on receiving the Best Poster Award at the National Conference on "Organic Synthesis 2025" (N-COS-2025), held on December 15-17, 2025.
RECENT ARTICLES
2026
Dhayalan, V.; Dual Catalytic Strategies for the Efficient Functionalization of Aromatic Carbonyl Compounds. Synlett 2026 (accepted)
Selvam Vasanth, Jenu Navyatha, Thanigaivel Senthilkumar, Palanisamy Sowntharya, Vasudevan Dhayalan, Organometallic Reagent-Mediated Functionalization of Aromatic Compounds in Continuous-Flow System. Chemical Engineering & Technology 2026 (accepted)
Jayshree Nandkumar Solanke, Aksa S Annie, Marappan Pradeep Kumar, Selvam Vasanth, Rambabu Dandela, and Vasudevan Dhayalan*. Amidines as Directing Group in C-H Activation and Their Application in Medicinal and Materials Chemistry. Eur. J. Org. Chem. 2026 (accepted)
Dhayalan, V.; Sengoden, M.; and Kathiresan, M.; Book Name: Comprehensive Organic Functional Group Transformations, 3rd Edition, (edited by Gary A. Molander) Chapter: 2.19: Vinyl and Aryl Metals. Book chapter 2026 (Elsevier Science) accepted.
Solanke, J. N.; Kumar, M. P.; Vasanth, S.; Raju, G.; Dhayalan, V.; Dandela, R., Metal-Free Green Synthesis of 4,5-Diaryl-1,3-Dioxolane-2-Thiones Scaffolds via NHC Catalysis. J. Heterocycl. Chem., 2026, https://doi.org/10.1002/jhet.70197
Annie, A. S.; Pradeep Kumar, M.; Vasanth, S.; Solanke, J.; Navyatha, J.; Gat, S.; Dandela, R.; Amaladass, P.; Dhayalan, V A Comprehensive Review of Recent Synthetic Strategies and Functionalization of Amidine. Asian. J. Org. Chem. 2026, 15, e70432
Vasudevan Dhayalan et al. Recent Advances in Catalytic Quadruple-Cascade Reactions for the Construction of Structurally Complex Organic Molecules, ChemistrySelect, 2026, 15, e73246.
Vishal S. Dodke, Jayshree Nandkumar Solanke, Savita Gat, Deepika Sharma, Rambabu Dandela, Vasudevan Dhayalan "Synthetic Strategies Toward NHO-Metal Complexes and Applications in Synthesis and Catalysis” Chemistry - An Asian Journal, 2026, 21, e70724.
Pitchamuthu Amaladass, Alphonse Lazar, Kuppusamy Thangaraju, Vasudevan Dhayalan* “Synthesis and Applications of Functionalized Dibenzothiophene S,S-Dioxides in Optoelectronics and Bioimaging” European Journal of Organic Chemistry 2026, 0, e202500949.
Vasudevan Dhayalan. The future of triple catalysis. ChemistrySelect, 2026, 11, e06696.
Jayshree Nandkumar Solanke, Savita Gat, Rambabu Dandela, Vasudevan Dhayalan* Recent Discovery on Metal-Free Construction of S-Aryl Phosphorothioate Diesters. Israel Journal of Chemistry 2026 accepted
Vasudevan Dhayalan,* Marappan Pradeep Kumar, Aksa S Annie, Alisa S. Sunagatullina, Vladimir Malakhov, Anja Hoffmann-Röder,* and Paul Knochel* Preparation and Reactivity of Organometallic Reagents Leading to Functionalized N-Heteroaromatics. Chemical Reviews. 2026, 126, 4, 2582–2652.
Vasudevan Dhayalan, Cooperative NHC and Photoredox Dual Catalysis for the Construc-tion of Carbonyl Compounds, ACS Omega 2026, 11, 10951-10970.
Vasudevan Dhayalan, Cooperative Triple Catalysis for Complex Molecule Construction and Late-Stage Functionalization" Organic & Biomolecular Chemistry 2026, 24, 296-318.
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2025
Vasudevan Dhayalan, "Visible-Light-Driven NHC and Organophotoredox Dual Catalysis for the Synthesis of Carbonyl Compounds" Beilstein Journal of Organic Chemistry 2025, 21, 2584–2603. https://doi.org/10.3762/bjoc.21.200.
Vasudevan Dhayalan, "Recent Advances in Strain-Release Functionalization of [1.1.1]Propellanes Using Organometallic Reagents." Synlett 2025. doi: 10.1055/a-2669-6239
Jayshree Nandkumar Solanke, Deepika Sharma, Nalinikant Patra, Rambabu Dandela, Vasudevan Dhayalan* Recent Advances in the Synthesis and Applications of Thiocarbonyl Compounds" Eur. J. Org. Chem. 2025 (DOI: 10.1002/ejoc.202500460R1)
Deepika Sharma, Jayshree Nandkumar Solanke, Savita Gat, Vasudevan Dhayalan*, and Rambabu Dandela. An Alternative Method for the Efficient Synthesis of Aminoindane-Based Chiral Triazolium Salts" ChemistrySelect, 2025 (DOI: 10.1002/slct.70759)
Jayshree Nandkumar Solanke, Selvam Vasanth, Marappan Pradeep Kumar, Mamidisetti Vishnuvardhan, Vasudevan Dhayalan,* and Rambabu Dandela" A green one-pot strategy for the direct synthesis of benzil" Asian. J. Org. Chem. 2025 (https://doi.org/10.1002/202400568)
Pitchamuthu Amaladass, Ragupathy Dhanusuraman, Alphonse Lazer, Devakumar John, Kuppusamy Thangaraju, Vasudevan Dhayalan ."A Comprehensive Exploration of Synthetic Methods for Functionalized Benzo[c]thiophene Derivatives and their Material Science Applications". Asian. J. Org. Chem. 2025 (https://doi.org/10.1002/ajoc.202500085)
2024
Aksa S Annie, Marappan Pradeep Kumar, Ramesh Adithya, Kaliswaran Vignesh, Vasudevan Dhayalan* Recent Synthetic Strategies for the Functionalization of Indole and Azaindole Scaffolds Asian. J. Org. Chem. 2024 (https://doi.org/10.1002/ajoc.202400694)
Vasudevan Dhayalan,* Vishal S. Dodke, Marappan Pradeep Kumar, Hatice Seher Korkmaz, Anja Hoffmann-Röder, Pitchamuthu Amaladass, Rambabu Dandela, Ragupathy Dhanusuramane and Paul Knochel* "Recent synthetic strategies for the functionalization of fused bicyclic heteroaromatics using organo-Li, -Mg and -Zn reagents" Chemical Society Review 2024 (DOI:10.1039/d4cs003369a) Impact factor: 40.4
Marappan Pradeep Kumar, Aksa S Annie, Vikash Kumar Bind, Ramesh Adithya, P Amaladass, Vasudevan Dhayalan* “A review on functionalization of benzo-5,6-fused bicyclic heteroaromatic compounds” Chemistry - An Asian Journal, 2024 (Accepted, n/a, e202400455).
Deepika Sharma, Rana Chatterjee, Vasudevan Dhayalan,* and Rambabu Dandela,* "Metal-free oxidative coupling of aryl acetylene with elemental sulphur and amines: A facile access to α-ketothioamides" Organic & Biomolecular Chemistry, 2024 (Accepted, https://doi.org/10.1039/D4OB00830H) (IF: 3.2)
E. V. Venkat Shivaji Ramarao, Jayshree Solanke, Rana Chatterjee, Savita Gat, Vasudevan Dhayalan, Rambabu Dandela "Metal-free efficient synthesis of aryl sulfonamides from N hydroxy sulfonamide and amines" Organic & Biomolecular Chemistry, 2024 (Accepted, https://doi.org/10.1039/D4OB00878B) (IF: 3.2)
Pradeep Kumar, M.; Annie, A. S.; Solanke, J. N.; Dandela, R.* Dhayalan, V.; "A Comprehensive Review on Selective Catalytic Methods for Functionalization of Adamantane Scaffolds" Asian. J. Org. Chem. 2024 (Accepted, DOI: 10.1002/ajoc.202400184) (IF: 4.1)
Dhayalan, V.; Dodke, V. S.; Sharma, D.; Dandela, R. “Recent advances in the preparation of air stable organozinc pivalates and their applications in organic synthesis” Eur. J. Org. Chem. 2024, (DOI: 10.1002/ejoc.202301263) (IF: 3.34)